Patient-derived organoids
Patient-derived organoids are miniature 3D versions of a patient's tumour grown in the lab.
Living biobanks of organoids (HUB, Broad) preserve genotype and drug response. Used for drug screening, CRISPR studies, and increasingly co-cultured with immune cells for immunotherapy testing.
How it works
Stem-cell-driven 3D culture in extracellular matrix with defined growth factors.
- Fidelity to patient tumour
- Scalable
- Lacks vasculature and full microenvironment
Latest papers
topQuery for this technology: (TITLE:"patient-derived organoid" OR ABSTRACT:"patient-derived organoid" OR TITLE:"patient-derived organoids" OR ABSTRACT:"patient-derived organoids" OR TITLE:"tumor organoid" OR ABSTRACT:"tumor organoid"). Results are unfiltered search hits about Patient-derived organoids, not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyPatient-derived xenografts
Shares An independent replication institute that re-tests key preclinical cancer findings before trials, Build laboratory models of the organs cancer spreads to, Barcode patient-derived tumours to watch which clones win under each drug, Champions Oncology.
- TechnologyCRISPR functional genomics
Shares Barcode patient-derived tumours to watch which clones win under each drug, A drug screen that only rewards killing sleeping cancer cells, Make in vivo metastasis screens a required step in drug discovery, Self-driving laboratories that run the cancer biology hypothesis loop autonomously.
- CollectionDepMap (Cancer Dependency Map)
Shares A drug screen that only rewards killing sleeping cancer cells, Make in vivo metastasis screens a required step in drug discovery, A public atlas of drug-pair responses across a thousand patient-derived organoids, An open engine that ranks every drug pair by predicted synergy before anyone runs a trial.
- CompanyCuresponse
Shares Test drugs on freshly cut slices of the patient's own tumour, Organoid-guided therapy at scale, Hold organoid drug tests to the same standard as a diagnostic test, Grow each trial patient's tumour as organoids to decide which platform arm opens next.
- InstitutionBroad Institute of MIT and Harvard
Shares Andrew J. Aguirre, Score every model system on how well it predicted real trial results, Pick the laboratory model that matches the patient, not the one to hand, An open model of every cancer cell state, built from perturbation atlases.
- TermModel organism
Shares Cell line, In vitro and in vivo, Organoid, Preclinical.
- BottleneckThe valley of death between lab and product
Shares An independent replication institute that re-tests key preclinical cancer findings before trials, Self-driving laboratories that run the cancer biology hypothesis loop autonomously, Reproducibility Project: Cancer Biology found that landmark preclinical results mostly shrank or vanished on replication, A funded organoid and PDX panel as the go/no-go gate before IND-enabling money.