An independent replication institute that re-tests key preclinical cancer findings before trials
Many cancer lab results cannot be reproduced, and trials built on them fail. Fund an independent institute that re-runs important experiments before anyone spends millions on humans.
The Reproducibility Project: Cancer Biology found that most high-profile preclinical results replicated only partially or not at all. Trials and companies are built on unreplicated findings. The proposal is a funded, independent replication institute with standing capacity in the common cancer model systems, which re-tests findings prioritised by their influence on planned trials or investments, publishes all results, and issues a replication grade that funders, investors and ethics committees can require before first-in-human studies.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
- The valley of death between lab and product · Most academic discoveries die before anyone tests them in people because nobody funds the middle step.
Pages like this
not linked directly; found by shared links- IdeaMulti-centre randomised animal trials before committing to a human trial
Shares Patient-derived xenografts, Preclinical results do not reproduce, The valley of death between lab and product.
- Key paperReproducibility Project: Cancer Biology found that landmark preclinical results mostly shrank or vanished on replication
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical results do not reproduce, The valley of death between lab and product.
- IdeaScore every model system on how well it predicted real trial results
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical results do not reproduce.
- IdeaSet aside 3% of grant budgets to replicate findings before translation
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical results do not reproduce, The valley of death between lab and product.
- IdeaSelf-driving laboratories that run the cancer biology hypothesis loop autonomously
Shares Patient-derived organoids, Preclinical results do not reproduce, The valley of death between lab and product.
- IdeaShared reference organoid and PDX panels that every lab can test against
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical results do not reproduce.
- InstitutionThe Jackson Laboratory Cancer Center
Shares Patient-derived xenografts, Preclinical results do not reproduce.
- IdeaPre-specified sample sizes for animal studies; no more 'representative' experiments
Shares Patient-derived xenografts, Preclinical results do not reproduce.