Run the mouse or organoid trial at the same time as the human trial
Instead of testing a drug in lab models first and hoping the results carry over, build the same models from trial participants and run both experiments in parallel to see how well the models predict.
Co-clinical trials generate patient-derived organoids or xenografts from enrolled participants and treat them with the trial regimen, with model results locked and blinded until the clinical readout. This produces a prospective, unbiased estimate of model predictive value, which the field currently lacks, and gives a resource for studying the responders and non-responders.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
- Biomarkers are not validated or standardised · Tests that decide who gets a drug are often not validated prospectively and are measured differently in every lab.
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not linked directly; found by shared links- IdeaTest drugs on the patient's own cancer cells when there is no trial to join
Shares Champions Oncology, Xilis, Patient-derived xenografts, Functional (ex vivo) drug testing.
- IdeaHold organoid drug tests to the same standard as a diagnostic test
Shares Xilis, Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaGrow each trial patient's tumour as organoids to decide which platform arm opens next
Shares Xilis, Patient-derived organoids to pick ADC payloads, Functional (ex vivo) drug testing, Patient-derived organoids.
- IdeaA funded organoid and PDX panel as the go/no-go gate before IND-enabling money
Shares Patient-derived organoids to pick ADC payloads, Patient-derived xenografts, Functional (ex vivo) drug testing, Patient-derived organoids.
- IdeaHumanised mice with an immune system matched to the tumour donor
Shares Champions Oncology, Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaAutomated combination discovery: patient-sample screens feeding Bayesian platform trials
Shares Patient-derived organoids to pick ADC payloads, Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- TechnologyOrganoid-guided therapy at scale
Shares Xilis, Patient-derived xenografts, Functional (ex vivo) drug testing, Patient-derived organoids.
- IdeaZebrafish avatars for a drug answer within a week
Shares Patient-derived xenografts, Functional (ex vivo) drug testing, Preclinical models that do not predict people.