Zebrafish avatars for a drug answer within a week
Tumour cells injected into transparent fish embryos grow in days, so several drugs can be compared in about a week, fast enough to help a patient who cannot wait.
Zebrafish patient-derived xenografts accept small cell numbers, are transparent for direct imaging of growth and metastasis, and give readouts in five to ten days at a fraction of mouse cost. Studies in colorectal and other cancers report concordance with patient outcomes. They lack an adaptive immune system and drug metabolism differs, so their role is rapid triage rather than definitive prediction.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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not linked directly; found by shared links- IdeaMake bespoke mouse cancer models in weeks with in vivo gene editing
Shares Patient-derived xenografts, Preclinical models that do not predict people, Pancreatic ductal adenocarcinoma.
- InstitutionAtrium Health Wake Forest Baptist Comprehensive Cancer Center
Shares Functional (ex vivo) drug testing, Preclinical models that do not predict people, Colorectal cancer.
- IdeaEvery resistance mechanism found in a patient must be rebuilt in the laboratory
Shares Functional (ex vivo) drug testing, Preclinical models that do not predict people.
- InstitutionThe Jackson Laboratory Cancer Center
Shares Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaRun the mouse or organoid trial at the same time as the human trial
Shares Patient-derived xenografts, Functional (ex vivo) drug testing, Preclinical models that do not predict people.
- IdeaPre-specified sample sizes for animal studies; no more 'representative' experiments
Shares Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaBuild laboratory models of the organs cancer spreads to
Shares Patient-derived xenografts, Preclinical models that do not predict people.
- IdeaHumanised mice with an immune system matched to the tumour donor
Shares Patient-derived xenografts, Preclinical models that do not predict people.