Cold Spring Harbor Laboratory
Basic-science cancer centre where RAS biology, tumour suppressors, and organoid models were advanced.
Tuveson's pancreatic cancer organoids, Lowe's p53/senescence, Vakoc's BET/SWI-SNF work.
- Pancreatic organoids
- p53 biology
Adrian Krainer invented the antisense drug nusinersen and studies how splicing errors drive cancer.
Bruce Stillman discovered how DNA replication starts, the process cancer cells push into overdrive.
Found that leukaemias depend on the chromatin reader BRD4, launching BET inhibitors, and mapped transcriptional addictions in sarcoma.
Built the pancreatic cancer organoid models now used to test drugs against a patient's own tumour.
Shows how diet reprogrammes intestinal stem cells and immunity to change colorectal cancer risk.
Studies how cancer wastes the whole body and how to stop it, one of the field's neglected problems.
Pages like this
not linked directly; found by shared links- IdeaGrow each trial patient's tumour as organoids to decide which platform arm opens next
Shares PDAC organoid pharmacotyping, Patient-derived organoids, Preclinical models that do not predict people, Pancreatic ductal adenocarcinoma.
- InstitutionStand Up To Cancer
Shares David A. Tuveson, Lustgarten Foundation, Pancreatic ductal adenocarcinoma.
- TermDisseminated tumour cells (DTCs)
Shares What decides which disseminated cells ever colonise?, Tumour dormancy, The metastatic cascade.
- PersonAndrew J. Aguirre
Shares Lustgarten Foundation, Patient-derived organoids, Pancreatic ductal adenocarcinoma.
- TrialPonsegromab phase 2 in cancer cachexia
Shares Treat cachexia before it starts, Cancer cachexia, Pancreatic ductal adenocarcinoma.
- TermHallmark: activating invasion and metastasis
Shares TGF-β signalling, Tumour dormancy, The metastatic cascade.
- IdeaScore every model system on how well it predicted real trial results
Shares Patient-derived organoids, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaSelf-driving laboratories that run the cancer biology hypothesis loop autonomously
Shares Patient-derived organoids, Preclinical results do not reproduce, Preclinical models that do not predict people.