Hallmark: activating invasion and metastasis
Cancer cells detach, invade, travel, and colonise other organs, the process responsible for most cancer deaths.
EMT programmes, matrix degradation, intravasation, dormancy, and colonisation. No approved drug targets metastasis directly; adjuvant therapy, MRD monitoring, and metastasis-directed radiotherapy are the clinical tools.
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not linked directly; found by shared links- TermHallmark: enabling replicative immortality
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: resisting cell death
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: inducing or accessing vasculature
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: evading growth suppressors
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark (2022): unlocking phenotypic plasticity
Shares Hallmarks of Cancer, Epithelial–mesenchymal transition & drug efflux and the tag hallmark.
- TermEnabling characteristic: genome instability and mutation
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: sustaining proliferative signalling
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: avoiding immune destruction
Shares Hallmarks of Cancer, TGF-β signalling and the tag hallmark.