Hallmark: inducing or accessing vasculature
Tumours grow their own blood supply, or co-opt existing vessels, to get oxygen and nutrients.
VEGF-driven sprouting angiogenesis, vessel co-option, and vasculogenic mimicry. Anti-VEGF drugs modestly extend survival alone and enable immunotherapy by normalising vessels; HIF-2α inhibition acts upstream in VHL-deficient RCC.
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not linked directly; found by shared links- TermHallmark: enabling replicative immortality
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: resisting cell death
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: evading growth suppressors
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: reprogramming cellular metabolism
Shares Hallmarks of Cancer, VHL / HIF oxygen sensing and the tag hallmark.
- TermHallmark: activating invasion and metastasis
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark: sustaining proliferative signalling
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermEnabling characteristic: genome instability and mutation
Shares The Hallmarks of Cancer: six capabilities every tumour must acquire, Hallmarks of Cancer and the tag hallmark.
- TermHallmark (2022): senescent cells
Shares Hallmarks of Cancer and the tag hallmark.