Disseminated tumour cells (DTCs)
Single cancer cells that have already spread to distant organs, often found in bone marrow years before any metastasis appears.
Detected by bone marrow aspiration (cytokeratin staining) in ~30% of early breast cancer patients and prognostic for relapse; most are dormant and non-proliferating. The biological substrate of MRD and late recurrence.
Pages like this
not linked directly; found by shared links- IdeaKeep them asleep: dormancy maintenance as adjuvant therapy
Shares Late recurrence, Tumour dormancy, The metastatic cascade, Minimal / molecular residual disease (MRD).
- IdeaBlunt the inflammation that wakes sleeping cancer cells
Shares Late recurrence, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- IdeaIntercepting late recurrence with ctDNA surveillance and oral SERDs
Shares Late recurrence, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- IdeaKeep dormant cells asleep instead of trying to kill them
Shares Late recurrence, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- IdeaBlock the recycling that keeps dormant cells alive
Shares Late recurrence, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- IdeaUse residual disease tests to decide who needs ten years of hormone therapy
Shares Late recurrence, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- TermInvasive
Shares Metastasis, Hallmark: activating invasion and metastasis.
- TermPrimary tumour
Shares Metastasis, The metastatic cascade.