Keep dormant cells asleep instead of trying to kill them
If we cannot kill sleeping cancer cells, we could try to keep them asleep for life. That would turn residual cancer into a harmless passenger.
Dormancy is an active transcriptional programme involving NR2F1, SOX9, TGF-beta2 and retinoic acid signalling. Combination all-trans retinoic acid plus a hypomethylating agent restored NR2F1 and enforced dormancy in head and neck and breast models from the Aguirre-Ghiso group, and both drugs are approved and cheap. The clinical question is whether enforced dormancy is durable and tolerable for years.
- Dormant cells and minimal residual disease · After a 'successful' treatment, cells can sleep for years then relapse. We can barely detect them and cannot target them.
- Metastasis is understood least and studied last · Metastasis causes about nine in ten cancer deaths but gets a small fraction of research money and almost no trials of its own.
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not linked directly; found by shared links- IdeaBlunt the inflammation that wakes sleeping cancer cells
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Shares Late recurrence, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
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Shares Late recurrence, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
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Shares Late recurrence, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
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Shares Late recurrence, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing, Prostate cancer.
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Shares Metastasis is understood least and studied last, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing, Prostate cancer.