What decides which disseminated cells ever colonise?
Most cancer cells that spread die or sleep forever; a few grow into lethal metastases. Nobody can yet tell them apart, and doing so would show whom to treat after surgery.
Bone marrow DTCs are common yet late relapse occurs in a minority. Candidate determinants: intrinsic stemness/plasticity programmes, niche interactions (perivascular, osteoblastic), immune surveillance capacity, and stochastic awakening.
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not linked directly; found by shared links- IdeaKeep them asleep: dormancy maintenance as adjuvant therapy
Shares The Mount Sinai Hospital / Tisch Cancer Institute, Late recurrence, Tumour dormancy, The metastatic cascade and the tags mechanism, open-question.
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Shares Memorial Sloan Kettering Cancer Center, Prostate cancer and the tags mechanism, open-question.
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Shares Memorial Sloan Kettering Cancer Center, Triple-negative breast cancer (TNBC) and the tags mechanism, open-question.
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Shares Single-cell & spatial profiling, Memorial Sloan Kettering Cancer Center and the tags mechanism, open-question.
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Shares Memorial Sloan Kettering Cancer Center, Triple-negative breast cancer (TNBC) and the tags mechanism, open-question.
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Shares Memorial Sloan Kettering Cancer Center, Prostate cancer and the tags mechanism, open-question.
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Shares Cold Spring Harbor Laboratory and the tags mechanism, open-question.
- IdeaMap metabolic dependencies in the patient, not the dish
Shares Memorial Sloan Kettering Cancer Center and the tags mechanism, open-question.