Is aneuploidy itself a druggable vulnerability?
Most cancers have the wrong number of chromosomes; normal cells do not. If that difference creates a specific weakness, a drug against it would spare normal tissue by definition.
Chromosomally unstable cells depend on KIF18A, the spindle assembly checkpoint, BCL-XL, and proteostasis; KIF18A inhibitors (sovilnesib, AMG 650) showed activity in platinum-resistant ovarian cancer in 2024-25.
Pages like this
not linked directly; found by shared links- IdeaCut the nerve supply to tumours with old drugs
Shares Stanford Health Care / Stanford Cancer Institute, Memorial Sloan Kettering Cancer Center and the tags mechanism, open-question.
- IdeaAttack extrachromosomal DNA, the engine of oncogene amplification
Shares Chromosomal instability & aneuploidy, Stanford Health Care / Stanford Cancer Institute and the tags mechanism, open-question.
- IdeaWhich patients' blood clones will become leukaemia after treatment?
Shares TP53, Memorial Sloan Kettering Cancer Center, Ovarian cancer and the tags mechanism, open-question.
- IdeaOne-two punch: clear senescent cells after chemotherapy
Shares Memorial Sloan Kettering Cancer Center, Ovarian cancer, Triple-negative breast cancer (TNBC) and the tags mechanism, open-question.
- IdeaIntercept cancer at the field stage
Shares The Francis Crick Institute, TP53 and the tags mechanism, open-question.
- IdeaWhat decides which disseminated cells ever colonise?
Shares Memorial Sloan Kettering Cancer Center, Triple-negative breast cancer (TNBC) and the tags mechanism, open-question.
- IdeaKill drug-tolerant persisters through ferroptosis
Shares Stanford Health Care / Stanford Cancer Institute and the tags mechanism, open-question.
- IdeaMap metabolic dependencies in the patient, not the dish
Shares Memorial Sloan Kettering Cancer Center and the tags mechanism, open-question.