peoplePerson
Adrian R. Krainer
Adrian Krainer invented the antisense drug nusinersen and studies how splicing errors drive cancer.
RNA biologist whose splice-switching oligonucleotide work produced nusinersen for spinal muscular atrophy (Breakthrough Prize 2019) and now targets splicing factors mutated in leukaemia and solid tumours.
Role
St. Giles Foundation Professor
Institution
Specialisms
RNA splicingAntisense oligonucleotidesSplicing in cancer
Profiles
| Title | Journal | Year |
|---|---|---|
| Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model | Genes & Development | 2010 |