Grow models from tumour cells in the blood when a biopsy is impossible
Some patients cannot have their tumour biopsied safely. Cancer cells captured from a blood sample can sometimes be grown into a model instead.
Circulating tumour cell-derived explants have been established in small cell lung cancer and reflect donor genomics and chemotherapy response, and CTC-derived organoids have been reported in prostate and breast cancer. Success rates depend on CTC counts, which are highest in exactly the aggressive diseases where biopsies are hardest. Scaling requires better capture, culture media and cryopreservation.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
- Acquired resistance to every therapy · Nearly every targeted therapy stops working within months to a few years as the tumour adapts.
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not linked directly; found by shared links- IdeaGrow blood-borne tumour cells to test drugs on the cells that actually spread
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people, Small-cell lung cancer.
- IdeaBuild laboratory models of the organs cancer spreads to
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaBarcode patient-derived tumours to watch which clones win under each drug
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaScore every model system on how well it predicted real trial results
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaPick the laboratory model that matches the patient, not the one to hand
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaDetect tumours changing cell type from RNA in the blood
Shares Small-cell lung cancer, Acquired resistance to every therapy, Liquid biopsy (ctDNA), Prostate cancer.
- IdeaAn open organoid bank for cancers too rare to have models
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaAn independent replication institute that re-tests key preclinical cancer findings before trials
Shares Patient-derived xenografts, Patient-derived organoids.