Grow blood-borne tumour cells to test drugs on the cells that actually spread
Drug tests normally use cells from the original tumour. Growing the rarer cells found in blood would test drugs against the cells that are actually travelling.
Cultures and xenografts derived from circulating tumour cells have been established in small-cell lung, breast and prostate cancer, with success rates that rise with CTC burden. They capture the metastasis-competent population and can be sampled repeatedly without a biopsy. Scaling the protocols, publishing failure rates honestly, and linking drug sensitivity to subsequent clinical course would create the first functional assay of metastatic competence.
- Metastasis is understood least and studied last · Metastasis causes about nine in ten cancer deaths but gets a small fraction of research money and almost no trials of its own.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
Pages like this
not linked directly; found by shared links- IdeaGrow models from tumour cells in the blood when a biopsy is impossible
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people, Small-cell lung cancer.
- InstitutionCancer Research UK Manchester Institute
Shares Fiona Blackhall, Caroline Dive, Patient-derived xenografts, Small-cell lung cancer.
- IdeaBuild laboratory models of the organs cancer spreads to
Shares Patient-derived xenografts, Patient-derived organoids, Metastasis is understood least and studied last, Preclinical models that do not predict people.
- IdeaCirculating tumour cell clearance as the phase 2 gate for anti-metastatic drugs
Shares Caroline Dive, Metastasis is understood least and studied last, Liquid biopsy (ctDNA), Prostate cancer.
- IdeaMake in vivo metastasis screens a required step in drug discovery
Shares Patient-derived xenografts, Patient-derived organoids, Metastasis is understood least and studied last, Preclinical models that do not predict people.
- IdeaZebrafish avatars for a drug answer within a week
Shares Patient-derived xenografts, Functional (ex vivo) drug testing, Preclinical models that do not predict people.
- IdeaRun the mouse or organoid trial at the same time as the human trial
Shares Patient-derived xenografts, Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaA funded organoid and PDX panel as the go/no-go gate before IND-enabling money
Shares Patient-derived xenografts, Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.