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Fiona Blackhall

Fiona Blackhall is a thoracic oncologist leading small-cell lung cancer trials and biomarker research at The Christie.

Fiona Blackhall leads thoracic oncology research at The Christie and the University of Manchester, with trials in small-cell and non-small-cell lung cancer and blood-based biomarkers.

Role
Professor of Thoracic Oncology, University of Manchester; Consultant, The Christie
Specialisms
Lung cancerSmall-cell lung cancerBiomarker-driven trials
Profiles

Key papers

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rctNew England Journal of Medicine 2023changed practice
DeLLphi-301: tarlatamab, a DLL3-targeting T-cell engager, in previously treated small-cell lung cancer

Patients with small-cell lung cancer that has relapsed after chemotherapy now have a drug that works far better than topotecan or lurbinectedin, and it is the first T-cell engager approved for a solid tumour. Treatment requires inpatient monitoring for the first doses because of cytokine release syndrome, which most centres now manage on a short-stay basis. It does not yet apply to first-line treatment, where trials are ongoing.

Connected

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cancers

2
Non-small-cell lung cancerSmall-cell lung cancer

institutions

3
Cancer Research UK Manchester InstituteInternational Association for the Study of Lung CancerThe Christie NHS Foundation Trust

ideas

1
Grow blood-borne tumour cells to test drugs on the cells that actually spread

key papers

1
DeLLphi-301: tarlatamab, a DLL3-targeting T-cell engager, in previously treated small-cell lung cancer