Pick the laboratory model that matches the patient, not the one to hand
Labs usually use whichever tumour models they already have. A searchable index that finds the model closest to a specific patient's tumour would make experiments more relevant.
Thousands of characterised models exist across DepMap, the Human Cancer Models Initiative, PDX repositories and institutional banks, but selection is driven by availability and habit. A matching engine indexing molecular profiles, ancestry, treatment history and microenvironment features would return the closest available models for a given tumour profile, and quantify how much of the clinical population has any representative model at all.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
- Trials do not represent the people who get cancer · Older, Black, Hispanic, Asian, rural, poor and multimorbid patients are under-represented, so results may not apply to them.
- Data silos · Records, scans, genomes and outcomes sit in separate systems that cannot talk. Every patient's experience is lost to the next.
Pages like this
not linked directly; found by shared links- IdeaScore every model system on how well it predicted real trial results
Shares Broad Institute of MIT and Harvard, Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaAn open organoid bank for cancers too rare to have models
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people, National Cancer Institute (NIH).
- IdeaBuild laboratory models of the organs cancer spreads to
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaBarcode patient-derived tumours to watch which clones win under each drug
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaGrow models from tumour cells in the blood when a biopsy is impossible
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaMulti-centre randomised animal trials before committing to a human trial
Shares Patient-derived xenografts, Preclinical models that do not predict people, National Cancer Institute (NIH).
- IdeaMake in vivo metastasis screens a required step in drug discovery
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaShared reference organoid and PDX panels that every lab can test against
Shares Patient-derived xenografts, Patient-derived organoids, Preclinical models that do not predict people.