Tumour-on-a-chip with blood flow to test whether big drugs actually get in
Large drugs such as antibody-drug conjugates must cross vessel walls and travel through dense tissue. A chip with flowing channels and human tissue can measure how far they get.
Microphysiological systems with perfusable endothelial channels, stromal fibroblasts and tumour spheroids reproduce interstitial pressure, matrix density and convective transport, the variables that determine ADC, radioligand and nanoparticle penetration. Standard flat cultures and mouse models cannot measure human tissue penetration directly, and penetration is a leading cause of clinical underperformance for large modalities.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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not linked directly; found by shared links- IdeaLinked human organ chips to predict side effects before people are dosed
Shares Payload (ADC), Patient-derived organoids, Preclinical models that do not predict people, Antibody-drug conjugate (ADC).
- TermCL2A
Shares Bystander effect (ADC), Sacituzumab govitecan, Antibody-drug conjugate (ADC).
- IdeaContinuous-flow synthesis of ultra-potent ADC payloads to ease the capacity squeeze
Shares Payload (ADC), Trastuzumab deruxtecan, Antibody-drug conjugate (ADC).
- IdeaDose and schedule optimisation trials specific to antibody-drug conjugates
Shares Sacituzumab govitecan, Payload (ADC), Trastuzumab deruxtecan, Antibody-drug conjugate (ADC).
- TermMMAF
Shares Bystander effect (ADC), Payload (ADC), Antibody-drug conjugate (ADC).
- TermDM1
Shares Bystander effect (ADC), Payload (ADC), Antibody-drug conjugate (ADC).
- TermDM4
Shares Bystander effect (ADC), Payload (ADC), Antibody-drug conjugate (ADC).
- IdeaUse antibodies to deliver protein-destroying drugs into the right cells
Shares Bystander effect (ADC), Payload (ADC), Antibody-drug conjugate (ADC).