A public atlas of drug-pair responses across a thousand patient-derived organoids
Build a large, openly shared dataset of how tumour organoids respond to drug pairs, so that anyone can look up which combinations might work for which tumour type.
Existing combination screens use cell lines (NCI ALMANAC, AZ-DREAM). Organoids preserve more of the patient's tumour biology but no large public pairwise dataset exists. A consortium screening 1,000 characterised organoids (with genomics, transcriptomics and, where available, donor outcome) against a matrix of 100 approved and late-stage drugs would be the training set for every in silico combination model.
- Too many combinations to test · There are thousands of possible drug pairs and sequences. Trials can test a few dozen a year.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
- Data silos · Records, scans, genomes and outcomes sit in separate systems that cannot talk. Every patient's experience is lost to the next.
Pages like this
not linked directly; found by shared links- IdeaEvery drug screen includes standard reference compounds whose performance is published
Shares Shared reference organoid and PDX panels that every lab can test against, DepMap (Cancer Dependency Map), Functional (ex vivo) drug testing, Preclinical models that do not predict people.
- IdeaAn open model bank for the rare tumours nobody has models for
Shares Cancer Models (PDCM Finder) & HCMI, DepMap (Cancer Dependency Map), Functional (ex vivo) drug testing, Patient-derived organoids.
- IdeaMake in vivo metastasis screens a required step in drug discovery
Shares Cancer Models (PDCM Finder) & HCMI, DepMap (Cancer Dependency Map), Patient-derived organoids, Preclinical models that do not predict people.
- IdeaA drug screen that only rewards killing sleeping cancer cells
Shares DepMap (Cancer Dependency Map), Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaPatient-derived organoids to pick ADC payloads
Shares An open engine that ranks every drug pair by predicted synergy before anyone runs a trial, Functional (ex vivo) drug testing, Patient-derived organoids, Too many combinations to test.
- IdeaA funded organoid and PDX panel as the go/no-go gate before IND-enabling money
Shares Cancer Models (PDCM Finder) & HCMI, Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.
- IdeaAutomated combination discovery: patient-sample screens feeding Bayesian platform trials
Shares Functional (ex vivo) drug testing, Patient-derived organoids, Too many combinations to test, Preclinical models that do not predict people.
- IdeaA bone marrow niche on a chip to study human dormancy
Shares Functional (ex vivo) drug testing, Patient-derived organoids, Preclinical models that do not predict people.