Every drug screen includes standard reference compounds whose performance is published
Labs testing new cancer compounds should always include a few well-known drugs as controls and report how those behaved, so results from different labs can be compared.
Drug sensitivity results for the same cell line and drug differ substantially between large screens (the CCLE versus GDSC discordance). A defined panel of reference compounds (with expected potency ranges per reference cell line) included in every published screen, and reported in a standard format, would allow cross-study calibration and reveal systematic differences in assay conditions.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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not linked directly; found by shared links- IdeaProve your cell lines are what you say they are, or the paper is not published
Shares A digital passport for every cell culture: identity, contamination status, passage number, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaA public atlas of drug-pair responses across a thousand patient-derived organoids
Shares Shared reference organoid and PDX panels that every lab can test against, DepMap (Cancer Dependency Map), Functional (ex vivo) drug testing, Preclinical models that do not predict people.
- IdeaA drug screen that only rewards killing sleeping cancer cells
Shares DepMap (Cancer Dependency Map), Functional (ex vivo) drug testing, CRISPR functional genomics, Preclinical models that do not predict people.
- IdeaBarcode every reagent lot so batch effects can be traced across experiments and labs
Shares A digital passport for every cell culture: identity, contamination status, passage number, Preclinical results do not reproduce.
- IdeaEvery resistance mechanism found in a patient must be rebuilt in the laboratory
Shares Functional (ex vivo) drug testing, CRISPR functional genomics, Preclinical models that do not predict people.
- InstitutionThe Jackson Laboratory Cancer Center
Shares CRISPR functional genomics, Preclinical results do not reproduce, Preclinical models that do not predict people.
- IdeaMake in vivo metastasis screens a required step in drug discovery
Shares DepMap (Cancer Dependency Map), CRISPR functional genomics, Preclinical models that do not predict people.
- Key paperDefining a Cancer Dependency Map: which genes each cancer cell line cannot live without
Shares DepMap (Cancer Dependency Map), Functional (ex vivo) drug testing, CRISPR functional genomics, Preclinical models that do not predict people.