A digital passport for every cell culture: identity, contamination status, passage number
Each batch of cells used in an experiment would carry a small digital record showing when it was authenticated, tested for contamination, and how many times it had been grown, attached to the published result.
Beyond identity, mycoplasma contamination and high passage number change cell behaviour and drug sensitivity. A lightweight standard (a signed JSON record with STR match, mycoplasma test date, passage, source and thaw date) generated by lab inventory software and attached to figures or methods as a persistent identifier would make culture provenance auditable and enable meta-analyses of how provenance affects results.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
- Preclinical models that do not predict people · Nine in ten cancer drugs that work in mice fail in humans. Our models are the reason.
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- InstitutionThe Jackson Laboratory Cancer Center
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