Barcode every reagent lot so batch effects can be traced across experiments and labs
Results can change when a supplier changes a batch of serum, antibody or growth factor. Recording which batch was used in each experiment, in a shared ledger, would let these effects be spotted.
Lot-to-lot variation in serum, media supplements, antibodies and enzymes is a recognised but untracked source of irreproducibility. A shared, machine-readable ledger of reagent lots (vendor, catalogue and lot number, hashed) linked to experiments and publications, populated by lab inventory software and vendor APIs, would let batch effects be detected across the community and would let vendors be held accountable for problem lots.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
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not linked directly; found by shared links- CollectionHuman Protein Atlas
Shares Only use antibodies proven to hit their target with knockout controls, Preclinical results do not reproduce.
- IdeaProve your cell lines are what you say they are, or the paper is not published
Shares A digital passport for every cell culture: identity, contamination status, passage number, Preclinical results do not reproduce.
- IdeaEvery drug screen includes standard reference compounds whose performance is published
Shares A digital passport for every cell culture: identity, contamination status, passage number, Preclinical results do not reproduce.