Preclinical
Everything done to a potential drug before it is given to a human: lab experiments, animal testing, and the safety and manufacturing work regulators require. Most candidates never make it out.
Preclinical development establishes that a drug hits its target, kills or slows tumours in cells and animals, can be made consistently, and is safe enough at the planned dose to test in people; toxicology in two species is normally required before the first human trial. 'Preclinical evidence' on this site means a claim supported only by such work, and the reader should discount it heavily: roughly 90% of drugs that enter human testing fail, and preclinical findings often do not reproduce even in other labs. Better models (organoids, humanised mice, patient-derived xenografts) and more rigorous reporting are attempts to shrink the gap between bench and bedside.
Pages like this
not linked directly; found by shared links- IdeaBarcode patient-derived tumours to watch which clones win under each drug
Shares Patient-derived xenografts, CRISPR functional genomics, Patient-derived organoids.
- CompanyHUB Organoids
Shares Organoid, Patient-derived organoids.
- IdeaMake in vivo metastasis screens a required step in drug discovery
Shares Patient-derived xenografts, CRISPR functional genomics, Patient-derived organoids.
- IdeaA synthetic lethality map for every cancer driver in every tissue context
Shares Patient-derived xenografts, CRISPR functional genomics, Patient-derived organoids.
- IdeaSet aside 3% of grant budgets to replicate findings before translation
Shares Patient-derived xenografts, CRISPR functional genomics, Patient-derived organoids.
- IdeaAn independent replication institute that re-tests key preclinical cancer findings before trials
Shares Patient-derived xenografts, Patient-derived organoids.
- TermRandomised trial
Shares Phase 1, 2 and 3 trials, Clinical trial.
- InstitutionThe Jackson Laboratory Cancer Center
Shares Patient-derived xenografts, CRISPR functional genomics.