FAPI PET
FAPI PET is a PET scan that lights up the scaffolding around almost any solid tumour, including cancers the standard sugar scan misses.
Quinoline-based FAP inhibitors (FAPI-04, FAPI-46, FAPI-74) labelled with 68Ga or 18F image cancer-associated fibroblasts. Superior to FDG in pancreatic, gastric, HCC, and peritoneal disease in head-to-head series. Registrational trials for 68Ga-FAPI-46 and 18F-FAPI-74 (Sofie) are underway. Pairs with FAP-targeted radioligands.
How it works
Small molecule binds FAP on stromal fibroblasts; rapid uptake, low background, minimal brain and liver signal.
- Pan-cancer, high contrast
- No fasting needed
- Sees desmoplastic tumours FDG misses
- Also uptake in fibrosis, healing, arthritis
- Reports stroma not tumour cells
- Not yet approved
Latest papers
topQuery for this technology: (TITLE:"FAPI PET" OR ABSTRACT:"FAPI PET" OR TITLE:"FAP inhibitor PET" OR ABSTRACT:"FAP inhibitor PET" OR TITLE:"68Ga-FAPI" OR ABSTRACT:"68Ga-FAPI" OR TITLE:"fibroblast activation protein PET" OR ABSTRACT:"fibroblast activation protein PET"). Results are unfiltered search hits about FAPI PET, not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyPSMA PET
Shares All India Institute of Medical Sciences, New Delhi, Postgraduate Institute of Medical Education and Research, Chandigarh, Uwe Haberkorn, TUM Klinikum rechts der Isar / CCC München.
- PathwayTGF-β signalling
Shares Cancer-associated fibroblasts (CAFs), What actually holds T cells at the tumour border?, Desmoplasia (tumour stroma), Invasion: proteases, adhesion & the invasive front.
- TechnologyTargeting tumour mechanics and pressure
Shares Desmoplasia (tumour stroma), Invasion: proteases, adhesion & the invasive front, Fibroblast activation, desmoplasia & matrix stiffness, FAP.
- TechnologyHER2 PET
Shares Shaoli Song, Molecular imaging roadmap: FDG → PSMA → FAP → antigen and immune PET, PET (positron emission tomography), Gastric & gastro-oesophageal junction cancer.
- TechnologyRadioligand therapy (beta emitters)
Shares Cancer-associated fibroblasts (CAFs), FAP theranostics as a pan-cancer stromal strategy, All India Institute of Medical Sciences, New Delhi, Postgraduate Institute of Medical Education and Research, Chandigarh.
- ProductLutetium-177 vipivotide tetraxetan
Shares Postgraduate Institute of Medical Education and Research, Chandigarh, Uwe Haberkorn, TUM Klinikum rechts der Isar / CCC München, University Hospital Düsseldorf / CIO Düsseldorf.
- TermImmune exclusion
Shares What actually holds T cells at the tumour border?, Fibroblast activation, desmoplasia & matrix stiffness, FAP, Tumour microenvironment (TME).
- TechnologyPET/MRI
Shares TUM Klinikum rechts der Isar / CCC München, Molecular imaging roadmap: FDG → PSMA → FAP → antigen and immune PET, PET (positron emission tomography).