FAP-2286 (177Lu / 68Ga)
A FAP-targeted theranostic pair: one version images almost any solid tumour, the other treats it with radiation.
Clovis (bankrupt 2022) then Novartis via 3B Pharmaceuticals. 177Lu-FAP-2286 LuMIERE phase 1/2 in solid tumours; cyclic peptide gives longer tumour retention than FAPI small molecules. Pancreatic, sarcoma, and breast cohorts.
1.Radioligand circulates and binds FAP on cancer-associated fibroblasts on tumour cells
- Route
- IV infusion (177Lu) or injection (68Ga)
- Schedule
- LuMIERE phase 1/2 dose escalation, cycles every 6 weeks
- Monitoring
- Blood counts, renal function
Source: clinicaltrials.gov/study/NCT04939610. Doses are for orientation; the current label governs.
- Jan 2023Filing / dealUS
Novartis acquires rights after Clovis bankruptcy source
| Adverse event |
|---|
| Anaemia |
| Thrombocytopenia |
| Fatigue |
| Nausea |
Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
| Country | Reimbursement | List price | Assistance |
|---|---|---|---|
| United States | Investigational | not disclosed | — |
List prices are manufacturer or Medicare figures where publicly disclosed; net prices after rebates are usually lower. Reimbursement changes; check the payer.
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"FAP-2286" OR ABSTRACT:"FAP-2286" OR TITLE:"177Lu / 68Ga" OR ABSTRACT:"177Lu / 68Ga") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAP-2286 (177Lu / 68Ga), not a curated reading list.
Pages like this
not linked directly; found by shared links- TermCancer-associated fibroblasts (CAFs)
Shares Invasion: proteases, adhesion & the invasive front, Fibroblast activation, desmoplasia & matrix stiffness, FAPI PET, FAP.
- IdeaA university cyclotron network with shared regulatory files for new tracers
Shares FAP theranostics as a pan-cancer stromal strategy, Uwe Haberkorn, Radiopharmaceutical roadmap: iodine → lutetium → actinium, FAPI PET.
- TermDesmoplasia (tumour stroma)
Shares Invasion: proteases, adhesion & the invasive front, Fibroblast activation, desmoplasia & matrix stiffness, FAPI PET, FAP.
- TechnologyCAR-T against stroma: fibroblasts and myeloid cells
Shares Fibroblast activation, desmoplasia & matrix stiffness, FAPI PET, FAP, Pancreatic ductal adenocarcinoma.
- TechnologyTargeting tumour mechanics and pressure
Shares Invasion: proteases, adhesion & the invasive front, Fibroblast activation, desmoplasia & matrix stiffness, FAP, Pancreatic ductal adenocarcinoma.
- PersonFrederik Giesel
Shares University Hospital Düsseldorf / CIO Düsseldorf, FAPI PET, FAP.
- PersonShaoli Song
Shares FAPI PET, FAP, Triple-negative breast cancer (TNBC).
- CompanySOFIE Biosciences
Shares FAPI PET, FAP, Pancreatic ductal adenocarcinoma.