Cancer-associated fibroblasts (CAFs)
The scaffolding cells that tumours recruit to build scar-like tissue around themselves. They feed the cancer, block drugs and immune cells, and carry the FAP protein that PET scans can now see.
Heterogeneous (myCAF, iCAF, apCAF); sources include resident fibroblasts, stellate cells, and mesenchymal stem cells. Secrete TGF-β, IL-6, CXCL12; deposit ECM. Depletion experiments show both pro- and anti-tumour roles, so targeting is moving toward reprogramming (vitamin D receptor agonists) and FAP-directed theranostics.
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not linked directly; found by shared links- TechnologyTargeting tumour mechanics and pressure
Shares Desmoplasia (tumour stroma), Invasion: proteases, adhesion & the invasive front, Fibroblast activation, desmoplasia & matrix stiffness, FAP.
- ProductFAP-2286 (177Lu / 68Ga)
Shares Invasion: proteases, adhesion & the invasive front, Fibroblast activation, desmoplasia & matrix stiffness, FAPI PET, FAP.
- TermImmune exclusion
Shares TGF-β signalling, Fibroblast activation, desmoplasia & matrix stiffness, FAP, Tumour microenvironment (TME).
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Shares Fibroblast activation, desmoplasia & matrix stiffness, FAPI PET, FAP.
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Shares TGF-β signalling, FAPI PET, FAP, Tumour microenvironment (TME).
- PathwayHippo–YAP/TAZ
Shares Invasion: proteases, adhesion & the invasive front, Fibroblast activation, desmoplasia & matrix stiffness, Tumour microenvironment (TME).
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Shares FAPI PET, FAP, Radioligand therapy (beta emitters).
- PersonUwe Haberkorn
Shares FAPI PET, FAP, Radioligand therapy (beta emitters).