Desmoplasia (tumour stroma)
The dense scar-like tissue that makes up most of a pancreatic tumour, walling off cancer cells from drugs and immune cells.
Cancer-associated fibroblasts, collagen, and hyaluronan can constitute 70-90% of PDAC volume, compressing vessels, limiting drug delivery, and excluding T cells. Stroma-depleting strategies failed or harmed (hedgehog inhibitors, PEGPH20 in HALO-301), revealing that stroma also restrains tumours. FAP-expressing fibroblasts are now an imaging and radioligand target rather than a depletion target.
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not linked directly; found by shared links- ProductFAP-2286 (177Lu / 68Ga)
Shares Invasion: proteases, adhesion & the invasive front, Fibroblast activation, desmoplasia & matrix stiffness, FAPI PET, FAP.
- TermImmune exclusion
Shares TGF-β signalling, Fibroblast activation, desmoplasia & matrix stiffness, FAP, Cold tumours: immune deserts and exclusion.
- PersonErik Sahai
Shares Soften the tissue that new metastases need in order to grow, Match therapy to the type of scar-forming cell in the tumour, FAP.
- TechnologyCAR-T against stroma: fibroblasts and myeloid cells
Shares Fibroblast activation, desmoplasia & matrix stiffness, FAPI PET, FAP, Pancreatic ductal adenocarcinoma.
- IdeaWhat actually holds T cells at the tumour border?
Shares TGF-β signalling, FAPI PET, FAP, Hot vs cold tumours.
- IdeaFAP theranostics as a pan-cancer stromal strategy
Shares FAPI PET, FAP, Cold tumours and the immunosuppressive microenvironment, Pancreatic ductal adenocarcinoma.
- PathwayTumour microenvironment (TME)
Shares Cancer-associated fibroblasts (CAFs), TGF-β signalling, Fibroblast activation, desmoplasia & matrix stiffness, FAPI PET.
- IdeaMake every cold tumour hot: a coordinated programme to reprogramme immune-excluded tumours
Shares FAP, Hot vs cold tumours, Cold tumours and the immunosuppressive microenvironment, Pancreatic ductal adenocarcinoma.