Erik Sahai
Cell biologist studying how the tumour's surroundings help cancer cells invade and resist drugs.
Erik Sahai uses intravital imaging and computational models to study fibroblast-tumour interactions, invasion, and the non-genetic plasticity that lets cancer cells survive targeted therapy.
| Title | Journal | Year |
|---|---|---|
| A framework for advancing our understanding of cancer-associated fibroblasts | Nature Reviews Cancer | 2020 |
Pages like this
not linked directly; found by shared links- TermConsensus molecular subtypes (CMS1-4)
Shares Match therapy to the type of scar-forming cell in the tumour, Epithelial–mesenchymal transition & drug efflux.
- TermDesmoplasia (tumour stroma)
Shares Soften the tissue that new metastases need in order to grow, Match therapy to the type of scar-forming cell in the tumour, FAP.
- PathwayInvasion: proteases, adhesion & the invasive front
Shares FAP, Epithelial–mesenchymal transition & drug efflux.
- PathwayThe metastatic cascade
Shares The Francis Crick Institute, Epithelial–mesenchymal transition & drug efflux.
- PathwayCancer stem cells & phenotypic plasticity
Shares The Francis Crick Institute, Epithelial–mesenchymal transition & drug efflux.
- BottleneckMetastasis is understood least and studied last
Shares Break the neutrophil DNA nets that catch tumour cells after surgery, Soften the tissue that new metastases need in order to grow, Epithelial–mesenchymal transition & drug efflux.