Break the neutrophil DNA nets that catch tumour cells after surgery
Surgery makes some immune cells throw out sticky DNA webs that trap travelling cancer cells and help them settle. Dissolving those webs during the operation might prevent some relapses.
Neutrophil extracellular traps capture circulating tumour cells and promote liver and lung seeding in multiple mouse models, and trap markers rise sharply after major cancer surgery. DNase I is an approved inhaled drug and PAD4 inhibitors are in development, so a perioperative net-dissolving window trial is quick and cheap to run.
- Metastasis is understood least and studied last · Metastasis causes about nine in ten cancer deaths but gets a small fraction of research money and almost no trials of its own.
- Dormant cells and minimal residual disease · After a 'successful' treatment, cells can sleep for years then relapse. We can barely detect them and cannot target them.
Pages like this
not linked directly; found by shared links- IdeaA blood test for the pre-metastatic niche
Shares Metastasis is understood least and studied last, Dormant cells and minimal residual disease, Liquid biopsy (ctDNA), Pancreatic ductal adenocarcinoma.
- IdeaTake the blood test, and give the drug, at the right time of day
Shares Circulating tumour DNA (ctDNA), Dormant cells and minimal residual disease, MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
- IdeaStrip the platelet coat off travelling tumour cells in ctDNA-positive patients
Shares Metastasis is understood least and studied last, Dormant cells and minimal residual disease, MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
- IdeaSoften the tissue that new metastases need in order to grow
Shares Erik Sahai, Metastasis is understood least and studied last, Pancreatic ductal adenocarcinoma.
- IdeaA test to tell true oligometastatic disease from hidden widespread spread
Shares Metastasis is understood least and studied last, Circulating tumour DNA (ctDNA), MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
- PersonSarah-Jane Dawson
Shares Circulating tumour DNA (ctDNA), MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
- IdeaA national residual-disease weather service: serial blood tests for every curatively treated patient, pooled
Shares Circulating tumour DNA (ctDNA), Dormant cells and minimal residual disease, MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
- IdeaBank yearly blood from cancer survivors so future tests can be validated
Shares Circulating tumour DNA (ctDNA), Dormant cells and minimal residual disease, MRD / molecular residual disease testing, Liquid biopsy (ctDNA).