Soften the tissue that new metastases need in order to grow
Cancer cells need stiff, cross-linked tissue scaffolding to settle and grow in a new organ. Blocking the enzymes that build it may stop new colonies taking hold.
LOX and LOXL2 cross-link collagen to create the stiff matrix required for metastatic outgrowth, and hypoxia-driven LOX secretion prepares bone and lung niches. An anti-LOXL2 antibody failed in fibrosis and in advanced pancreatic cancer, but was never tested in the prevention setting where the biology predicts benefit and the target burden is small.
- Metastasis is understood least and studied last · Metastasis causes about nine in ten cancer deaths but gets a small fraction of research money and almost no trials of its own.
- Failures are hidden · Negative trials, failed drugs and abandoned programmes are rarely published, so the same mistakes are repeated.
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not linked directly; found by shared links- IdeaMatch therapy to the type of scar-forming cell in the tumour
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Shares Epithelial–mesenchymal transition & drug efflux, Metastasis is understood least and studied last, HR-positive / HER2-negative breast cancer.
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Shares Metastasis is understood least and studied last, Pancreatic ductal adenocarcinoma, HR-positive / HER2-negative breast cancer.
- IdeaStrip the platelet coat off travelling tumour cells in ctDNA-positive patients
Shares Epithelial–mesenchymal transition & drug efflux, Metastasis is understood least and studied last, HR-positive / HER2-negative breast cancer.
- PersonMax S. Wicha
Shares Epithelial–mesenchymal transition & drug efflux, HR-positive / HER2-negative breast cancer.
- IdeaLosartan to loosen the stroma of pancreatic cancer before chemotherapy: a phase 3
Shares Epithelial–mesenchymal transition & drug efflux, Pancreatic ductal adenocarcinoma.
- IdeaPerioperative beta-blocker plus COX-2 inhibitor to reduce metastasis after surgery
Shares Metastasis is understood least and studied last, HR-positive / HER2-negative breast cancer.