Immunogenic cell death
Immunogenic cell death is a way of dying that alerts the immune system, unlike quiet apoptosis.
Marked by calreticulin exposure, ATP and HMGB1 release, type I interferon. Induced by anthracyclines, oxaliplatin, radiation, some ADC payloads, oncolytic viruses, photoimmunotherapy. Basis for chemo-IO and ADC-IO synergy.
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not linked directly; found by shared links- TermAbscopal effect
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Shares Histotripsy as an immune primer, Mechanically pulverise one tumour with ultrasound to wake the immune system, In situ vaccination.