termsTerm
Abscopal effect
When irradiating one tumour causes untreated tumours elsewhere to shrink, via the immune system.
Rare alone; more frequent with checkpoint inhibitors. Mechanism via cGAS-STING, antigen release, and T-cell priming. Rationale for SBRT + IO trials, with mixed results (PEMBRO-RT positive, others negative).
Immunology: what this kind of term is about · animated schematic, not to scale
Category
Immunology
technologies
5institutions
2pathways
1terms
1pairings
1ideas
5A neutral platform trial for radiotherapy plus immunotherapy combinationsMechanically pulverise one tumour with ultrasound to wake the immune systemPhotoimmunotherapy as an in situ vaccine with PD-1 blockadePick the radiation dose that switches the immune alarm on, not offTurn one tumour into a vaccine to treat all the others