Radiotherapy + immunotherapy
Radiation turns the irradiated tumour into a vaccine; immunotherapy spreads the response.
PACIFIC (durvalumab after chemoradiation, OS benefit), KEYNOTE-A18 (cervical), NRG/RTOG trials. Abscopal responses with SBRT + IO are real but inconsistent; PEMBRO-RT positive, others negative. Timing, dose, and site matter.
Pages like this
not linked directly; found by shared links- InstitutionShandong Cancer Hospital and Institute
Shares Abscopal effect, SBRT / SABR (stereotactic radiotherapy), Small-cell lung cancer, Immune checkpoint inhibitors.
- PairingADC + checkpoint inhibitor
Shares An oncology patent pool for combination trials across companies, cGAS–STING innate sensing, Pembrolizumab, Immune checkpoint inhibitors.
- TrialKEYNOTE-A18 / ENGOT-cx11 / GOG-3047
Shares PD-1 blockade + chemoradiation (locally advanced cervical cancer), Cervical cancer, Pembrolizumab, Immune checkpoint inhibitors.
- TechnologyLattice and GRID radiotherapy
Shares Abscopal effect, SBRT / SABR (stereotactic radiotherapy), Immune checkpoint inhibitors.
- PairingPD-1 blockade + chemotherapy in PD-L1-low NSCLC
Shares Durvalumab, Pembrolizumab, Immune checkpoint inhibitors, Non-small-cell lung cancer.
- InstitutionIRCCS Humanitas Research Hospital
Shares Durvalumab, SBRT / SABR (stereotactic radiotherapy), Immune checkpoint inhibitors, Non-small-cell lung cancer.
- IdeaPhotoimmunotherapy as an in situ vaccine with PD-1 blockade
Shares Abscopal effect, Pembrolizumab, Immune checkpoint inhibitors.
- IdeaA permanent neutral non-profit sponsor for multi-company platform trials
Shares An oncology patent pool for combination trials across companies, A neutral platform trial for radiotherapy plus immunotherapy combinations.