Turn one tumour into a vaccine to treat all the others
Injecting immune-activating agents into a single tumour, plus a small dose of radiation, can teach the immune system to attack tumours elsewhere in the body.
The in situ vaccine combination of Flt3L to recruit dendritic cells, low-dose radiotherapy to release antigen, and a TLR3 agonist to mature the dendritic cells produced systemic regressions in indolent lymphoma in a phase 1/2 at Mount Sinai. The approach needs no antigen identification and no manufacturing, and has never been properly tested in solid tumours where antigen release by radiotherapy is well characterised.
- Cold tumours and the immunosuppressive microenvironment · Most tumours keep the immune system out or asleep, so immunotherapy helps only a minority.
- No one can predict who responds to immunotherapy · Checkpoint drugs cure some patients and do nothing for most. We still cannot tell the two apart before treating.
Pages like this
not linked directly; found by shared links- IdeaPick the radiation dose that switches the immune alarm on, not off
Shares Abscopal effect, Immunogenic cell death, SBRT / SABR (stereotactic radiotherapy), Cold tumours and the immunosuppressive microenvironment.
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Shares Abscopal effect, Immunogenic cell death, Cold tumours and the immunosuppressive microenvironment, Head and neck squamous cell carcinoma.
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Shares Abscopal effect, Immunogenic cell death, STING & innate immune agonists, SBRT / SABR (stereotactic radiotherapy).
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Shares STING & innate immune agonists, Hot vs cold tumours, Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy.
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Shares Hot vs cold tumours, Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy, Sarcomas (soft tissue, bone, GIST).
- InstitutionShandong Cancer Hospital and Institute
Shares Abscopal effect, SBRT / SABR (stereotactic radiotherapy), Head and neck squamous cell carcinoma, Immune checkpoint inhibitors.
- TechnologyLattice and GRID radiotherapy
Shares Abscopal effect, SBRT / SABR (stereotactic radiotherapy), Immune checkpoint inhibitors.