STING & innate immune agonists
Drugs that trigger the cell's built-in 'virus alarm' inside tumours to summon immune cells.
Intratumoural STING agonists (ADU-S100, MK-1454) disappointed; systemic and antibody-conjugated versions (TAK-500, XMT-2056), TLR9 agonists (vidutolimod), and CD40 agonists (sotigalimab) continue. The cGAS-STING pathway also mediates the immune effects of radiation and ADCs.
How it works
Cyclic dinucleotide or non-nucleotide agonists activate STING → TBK1 → IRF3 → type I interferon.
- Converts cold tumours in models
- Weak clinical activity to date
Latest papers
topQuery for this technology: (TITLE:"STING agonist" OR ABSTRACT:"STING agonist" OR TITLE:"cGAS-STING" OR ABSTRACT:"cGAS-STING") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STING & innate immune agonists, not a curated reading list.
Pages like this
not linked directly; found by shared links- TechnologyIntratumoural gene electrotransfer (IL-12 plasmid)
Shares Cold tumours: immune deserts and exclusion and the tag frontier.
- TechnologyMetabolic therapy: starving the tumour of a nutrient
Shares Harold C. Simmons Comprehensive Cancer Center, UT Southwestern and the tag frontier.
- TechnologyIn vivo CAR-T
Shares Immunotherapy roadmap: Coley's toxins → checkpoint inhibitors → engineered immunity and the tag frontier.
- TechnologySpatial-omics-guided treatment selection
Shares Hot vs cold tumours and the tag frontier.
- TechnologyMicrobiome modulation to unlock immunotherapy
Shares Hot vs cold tumours and the tag frontier.
- TechnologyOncolytic viruses
Shares Engineered bacteria as living cancer drugs, In situ vaccination, Make every cold tumour hot: a coordinated programme to reprogramme immune-excluded tumours, The cancer-immunity cycle.
- TermImmunogenic cell death
Shares Turn one tumour into a vaccine to treat all the others, In situ vaccination, cGAS–STING innate sensing, The cancer-immunity cycle.
- TechnologyCytokines & engineered cytokines
Shares Engineered bacteria as living cancer drugs, Inhaled immune therapy to make the lung hostile to arriving tumour cells, Engineered bacteria that live in tumours and manufacture drugs there, In situ vaccination.