Immune-stimulating antibody conjugate (ISAC)
An immune-stimulating antibody conjugate (ISAC) is an ADC whose payload wakes up the immune system inside the tumour rather than poisoning the cell.
TLR7/8 agonist conjugates (Bolt's BDC-1001, HER2; Silverback) and STING agonist conjugates (Mersana XMT-2056, Takeda TAK-500) aim to convert cold tumours. Early results have been modest; dose-limiting systemic cytokine release and the need for antigen-presenting-cell engagement are challenges.
How it works
Antibody-targeted delivery of innate immune agonists to tumour-resident myeloid cells.
- Durable immune memory in principle
- Combinable with checkpoint inhibitors
- Weak single-agent activity so far
Latest papers
topQuery for this technology: (TITLE:"immune-stimulating antibody conjugate" OR ABSTRACT:"immune-stimulating antibody conjugate" OR TITLE:"ISAC" OR ABSTRACT:"ISAC" OR TITLE:"TLR agonist antibody conjugate" OR ABSTRACT:"TLR agonist antibody conjugate") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Immune-stimulating antibody conjugate (ISAC), not a curated reading list.
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