Laurence Zitvogel
Immunologist who showed that the gut microbiome shapes responses to immunotherapy and chemotherapy.
Laurence Zitvogel co-discovered immunogenic cell death with Guido Kroemer and led the studies linking gut microbiota composition to checkpoint-inhibitor response, opening the field of microbiome-directed cancer therapy.
| Title | Journal | Year |
|---|---|---|
| Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors | Science | 2018 |
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not linked directly; found by shared links- IdeaCapture diet, fibre and antibiotic exposure in every immunotherapy pivotal trial
Shares Protect the gut flora of patients about to start immunotherapy, Test a high-fibre diet as an immunotherapy adjunct, Dietary fibre and the gut microbiome for immunotherapy response, Immune checkpoint inhibitors.
- TrialMIMic-01: healthy-donor FMT plus anti-PD-1, first-line melanoma
Shares Take faecal transplant plus immunotherapy to a definitive trial, Faecal microbiota transplantation for PD-1 non-responders, Immune checkpoint inhibitors.
- TrialFMT plus pembrolizumab in anti-PD-1-refractory melanoma (Pittsburgh)
Shares Take faecal transplant plus immunotherapy to a definitive trial, Faecal microbiota transplantation for PD-1 non-responders, Immune checkpoint inhibitors.
- TechnologyProbiotics, antibiotics and stewardship around immunotherapy
Shares Protect the gut flora of patients about to start immunotherapy, Dietary fibre and the gut microbiome for immunotherapy response, Immune checkpoint inhibitors.
- PersonFabrice Barlesi
- TechnologyMicrobiome modulation to unlock immunotherapy
Shares Faecal microbiota transplantation for PD-1 non-responders, Dietary fibre and the gut microbiome for immunotherapy response, Immune checkpoint inhibitors.
- IdeaMicrobiome transplant as a routine immunotherapy adjunct
Shares Faecal microbiota transplantation for PD-1 non-responders, Gustave Roussy.
- PathwayMicrobiome–tumour interactions
Shares Faecal microbiota transplantation for PD-1 non-responders, Dietary fibre and the gut microbiome for immunotherapy response, Gustave Roussy.