Microbiome transplant as a routine immunotherapy adjunct
Stool transplants from immunotherapy responders have rescued some non-responders in melanoma. If defined bacterial cocktails work as well, every immunotherapy patient could get one.
Phase 1/2 FMT studies (Davar, Baruch) converted 20-40% of refractory melanoma patients; defined consortia (SER-155, VE800) and diet trials are ongoing; mechanisms and durability are unclear.
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