Test a high-fibre diet as an immunotherapy adjunct
People who eat more fibre appear to respond better to immunotherapy, while some probiotic supplements may do the opposite. A proper trial would settle it.
Observational data in melanoma associate higher dietary fibre intake with improved checkpoint response, and over-the-counter probiotic use with worse response, with supporting mouse experiments. Diet is a cheap, scalable and modifiable exposure but has never been tested randomly alongside checkpoint therapy with microbiome and immune endpoints. Adherence measurement, through stool short-chain fatty acids, makes a rigorous trial possible.
- No one can predict who responds to immunotherapy · Checkpoint drugs cure some patients and do nothing for most. We still cannot tell the two apart before treating.
- Cold tumours and the immunosuppressive microenvironment · Most tumours keep the immune system out or asleep, so immunotherapy helps only a minority.
- No incentive to repurpose cheap drugs · Old, cheap drugs with anti-cancer signals never get the trials they need because no one profits from the result.
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not linked directly; found by shared links- IdeaProtect the gut flora of patients about to start immunotherapy
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Shares Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy, Melanoma, Immune checkpoint inhibitors.