Test protein and resistance training during immunotherapy
Muscle is an immune organ as well as a movement organ. Building it during immunotherapy might improve how well the treatment works, not just how patients feel.
Muscle secretes myokines including interleukin-15 and irisin that affect immune cell function, and low muscle mass is associated with poorer checkpoint inhibitor outcomes in several retrospective series. Whether that association is causal or simply reflects disease burden is unknown, and a randomised exercise and protein intervention during checkpoint therapy would answer it while also improving function.
- Cachexia, toxicity and the limits of the patient · Patients often die of wasting or cannot tolerate the doses that would work. Treating the patient, not just the tumour, lags far behind.
- No one can predict who responds to immunotherapy · Checkpoint drugs cure some patients and do nothing for most. We still cannot tell the two apart before treating.
- Cold tumours and the immunosuppressive microenvironment · Most tumours keep the immune system out or asleep, so immunotherapy helps only a minority.
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not linked directly; found by shared links- IdeaUse a hypoxia scan to pick patients for adenosine-pathway drugs
Shares Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy, Renal cell carcinoma, Immune checkpoint inhibitors.
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Shares No one can predict who responds to immunotherapy, Renal cell carcinoma, Melanoma, Immune checkpoint inhibitors.
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Shares No one can predict who responds to immunotherapy, Melanoma, Immune checkpoint inhibitors, Non-small-cell lung cancer.
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Shares Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy, Renal cell carcinoma, Melanoma.
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Shares Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy, Melanoma, Immune checkpoint inhibitors.
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Shares No one can predict who responds to immunotherapy, Renal cell carcinoma, Melanoma, Immune checkpoint inhibitors.
- IdeaCombine the new anti-wasting antibody with exercise and protein
Shares Structured exercise prescribed like a drug in all curative-intent cancer care, Cachexia, toxicity and the limits of the patient, Exercise & lifestyle oncology, Non-small-cell lung cancer.
- IdeaTrials of structured cognitive rehabilitation for cancer-related cognitive impairment
Shares Structured exercise prescribed like a drug in all curative-intent cancer care, Exercise & lifestyle oncology.