Use a hypoxia scan to pick patients for adenosine-pathway drugs
Tumours starved of oxygen produce a chemical that switches immune cells off. A scan can show which tumours are starved, and those are the ones to treat with blockers.
Hypoxia drives CD73-mediated adenosine production and A2A receptor signalling that suppresses T cells and natural killer cells. Adenosine-axis drugs have given inconsistent phase 2 results in unselected populations. Hypoxia PET tracers and validated hypoxia gene signatures could select the patients whose tumours actually run this pathway.
- Cold tumours and the immunosuppressive microenvironment · Most tumours keep the immune system out or asleep, so immunotherapy helps only a minority.
- No one can predict who responds to immunotherapy · Checkpoint drugs cure some patients and do nothing for most. We still cannot tell the two apart before treating.
- Biomarkers are not validated or standardised · Tests that decide who gets a drug are often not validated prospectively and are measured differently in every lab.
Pages like this
not linked directly; found by shared links- IdeaTest protein and resistance training during immunotherapy
Shares Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy, Renal cell carcinoma, Immune checkpoint inhibitors.
- IdeaWatch the immune system's response in the blood three weeks in
Shares RNA sequencing & expression profiling, No one can predict who responds to immunotherapy, Biomarkers are not validated or standardised, Immune checkpoint inhibitors.
- IdeaTreat immunotherapy side-effects without wiping out the response
Shares No one can predict who responds to immunotherapy, Renal cell carcinoma, Immune checkpoint inhibitors, Non-small-cell lung cancer.
- IdeaGrow immune command posts inside tumours
Shares Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy, Renal cell carcinoma, Immune checkpoint inhibitors.
- TechnologyCAIX PET (89Zr-girentuximab)
Shares VHL / HIF oxygen sensing, PET (positron emission tomography), Renal cell carcinoma.
- IdeaTest a high-fibre diet as an immunotherapy adjunct
Shares Cold tumours and the immunosuppressive microenvironment, No one can predict who responds to immunotherapy, Immune checkpoint inhibitors, Non-small-cell lung cancer.
- InstitutionCentre hospitalier de l'Université de Montréal (CHUM)
Shares No one can predict who responds to immunotherapy, Immune checkpoint inhibitors, Prostate cancer, Non-small-cell lung cancer.
- IdeaProtect the gut flora of patients about to start immunotherapy
Shares No one can predict who responds to immunotherapy, Renal cell carcinoma, Immune checkpoint inhibitors, Non-small-cell lung cancer.