ProtecT
Showed that men with screen-detected prostate cancer die of it rarely, whether monitored or treated, establishing active surveillance.
1,643 men; 15-year prostate-cancer mortality ~3% in all arms (NEJM 2023); treatment halved metastasis but at the cost of side effects; ~60% of monitoring patients eventually treated.
- 3.1 vs 2.2 out of 100 alive at 15 years with Active monitoring compared with Prostatectomy; 0.9 more per 100.
- Roughly one extra person helped for every 111 treated. That is a rough figure taken from the two percentages, not a guarantee for any one person.
- Other groups: Radiotherapy 2.9 of 100.
- Overall survival counts deaths from any cause, so it is the most direct measure of whether a treatment helps people live longer.
- These results apply to the people the trial enrolled: PSA-detected localised prostate cancer: active monitoring vs prostatectomy vs radiotherapy. People in a different situation may not see the same effect.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
1,643 participants enrolled.
No significant difference between arms
Source| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Prostate-cancer-specific mortality at 15 yearsprimary | Active monitoring | 545 | 3.1% | — | — | link |
| Prostatectomy | 553 | 2.2% | ||||
| Radiotherapy | 545 | 2.9% |
Pages like this
not linked directly; found by shared links- TermGleason score and Grade Group
Shares Radical prostatectomy, Active surveillance and observation, Active surveillance, Prostate cancer.
- TermGleason score / Grade Group
Shares Active surveillance, Overdiagnosis and false alarms, Prostate cancer.
- TechnologyMultiparametric prostate MRI (PI-RADS)
Shares Active surveillance, Overdiagnosis and false alarms, Prostate cancer.
- TermDuctal carcinoma in situ (DCIS)
Shares Active surveillance and observation, Active surveillance.
- TermMGUS and smouldering myeloma
Shares Active surveillance and observation, Active surveillance.
- IdeaTest whether calling Gleason 6 'not cancer' changes what men choose
- IdeaModern autopsy studies to measure how much silent cancer people carry
- TrialSANO
Shares Active surveillance and observation, Active surveillance, Surgery and radiotherapy cure most, get least.