Squamous cell carcinoma (SCC)
Cancer arising from the flat, scale-like cells that form the skin and line the mouth, throat, food pipe, airways, cervix and anus. Smoking, alcohol, sun and HPV are its main causes.
Squamous carcinomas of the head and neck, oesophagus (ESCC, most of the world's cases), lung (about a quarter of NSCLC), cervix, anus, penis and skin share a biology dominated by TP53 loss, CDKN2A loss and, in HPV-driven sites, viral E6/E7; they rarely carry the kinase drivers seen in adenocarcinoma, so chemotherapy, radiotherapy and immunotherapy remain their backbone. Skin SCC responds unusually well to PD-1 blockade (cemiplimab) because of its very high UV mutation load. Squamous histology in lung cancer excludes pemetrexed and bevacizumab.
Pages like this
not linked directly; found by shared links- TermSquamous cell carcinoma
Shares Histology, Oesophageal cancer, Cervical cancer, Head and neck squamous cell carcinoma.
- TermTumour differentiation (well / moderately / poorly differentiated)
- InstitutionZhejiang Cancer Hospital
Shares Oesophageal cancer, Cervical cancer, Head and neck squamous cell carcinoma, Non-small-cell lung cancer.
- TermCore needle biopsy and fine-needle aspiration (FNA)
- TermHead and neck subsites (oral cavity, oropharynx, larynx)
Shares HPV status (HPV-positive / HPV-negative), Head and neck squamous cell carcinoma.
- TermDysplasia (pre-cancerous change)
Shares HPV status (HPV-positive / HPV-negative), Oesophageal cancer, Cervical cancer.
- InstitutionChang Gung Memorial Hospital
Shares Oesophageal cancer, Head and neck squamous cell carcinoma, Non-small-cell lung cancer.
- InstitutionHealthCare Global Enterprises
Shares Cervical cancer, Head and neck squamous cell carcinoma, Non-small-cell lung cancer.