Core needle biopsy and fine-needle aspiration (FNA)
Taking a sliver of tissue (core) or a few cells (fine-needle aspiration) through a needle guided by ultrasound, CT or MRI, to diagnose the cancer and test its markers without surgery.
Core biopsy preserves tissue architecture and gives enough material for immunohistochemistry (ER, PR, HER2, PD-L1) and genomic panels, so it is the standard for breast, prostate (MRI-targeted), lung and liver lesions. FNA gives cytology only and suits thyroid nodules (Bethesda system) and lymph nodes. Bone marrow aspirate and trephine biopsy diagnose and monitor leukaemias and myeloma. Re-biopsy at progression identifies resistance mechanisms (T790M, small-cell transformation) when liquid biopsy is uninformative.
Pages like this
not linked directly; found by shared links- TermSquamous cell carcinoma (SCC)
- TermAdenocarcinoma
- TermBiopsy
Shares Histology, Histopathology & immunohistochemistry, Liquid biopsy (ctDNA).
- TechnologycfDNA fragmentomics
- IdeaRe-test the metastasis, not the old primary, before every change of treatment
Shares Histopathology & immunohistochemistry, Liquid biopsy (ctDNA).
- TechnologyPre-analytics: blood-collection tubes and tissue fixation
Shares Histopathology & immunohistochemistry, Liquid biopsy (ctDNA).
- PathwayClonal haematopoiesis (CHIP)
- TermImmunohistochemistry (IHC)