HPV status (HPV-positive / HPV-negative)
Whether a cancer is caused by human papillomavirus. HPV-positive throat cancers are a different, far more curable disease than smoking-related ones, and the virus's DNA in blood can track the cancer.
Persistent high-risk HPV (types 16 and 18 mainly) causes virtually all cervical cancer and rising shares of oropharyngeal, anal, vulval and penile cancers; p16 immunohistochemistry is the surrogate marker in the oropharynx. HPV-positive oropharyngeal cancer has 3-year survival above 80% and its own AJCC staging, so trials test de-escalating radiotherapy dose or omitting chemotherapy, none of which has yet succeeded in a randomised trial. Circulating HPV DNA (ctHPV) detects recurrence months before imaging. HPV vaccination and HPV-based cervical screening are the route to eliminating cervical cancer.
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not linked directly; found by shared links- TermPlasma EBV DNA
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- IdeaEliminate infection-caused cancers: HPV, hepatitis B and C, H. pylori and EBV
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- IdeaSwitch every country to single-dose HPV vaccination and add catch-up to age 26
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- InstitutionPhilippine General Hospital
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- InstitutionInstitut National d'Oncologie, Rabat
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