Use a polygenic risk score to set when screening starts
Common gene variants shift a person's cancer risk several-fold. A one-time genetic score could tell each person when to start breast, bowel or prostate screening.
Polygenic scores reclassify risk for breast, prostate, and colorectal cancer, and BARCODE1 showed PRS-selected prostate screening finds clinically significant disease. Propose national programmes assigning screening start age by PRS plus family history, with a pragmatic trial comparing PRS-tailored to age-based invitation.
- Inherited risk is mostly unidentified · Most people who carry a high-risk cancer gene do not know it until they or a relative gets cancer.
- Most lethal cancers are found late · Screening exists for only a few cancers. Pancreatic, ovarian, liver, oesophageal and most lung cancers are found when cure is unlikely.
Pages like this
not linked directly; found by shared links- IdeaMRI-first prostate screening with genetic pre-selection
Shares The Institute of Cancer Research, Germline (hereditary) testing, Most lethal cancers are found late, Prostate cancer.
- IdeaOncology teams order germline tests; tele-genetic counsellors handle the results
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing, HR-positive / HER2-negative breast cancer, Colorectal cancer.
- IdeaAutomatic germline testing for every cancer type where it changes care
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing, Prostate cancer, Colorectal cancer.
- IdeaFamily history collected by app and matched to testing criteria automatically
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaBan life and disability insurers from using genetic results
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- InstitutionInstituto Português de Oncologia do Porto Francisco Gentil
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing, Prostate cancer, HR-positive / HER2-negative breast cancer.
- IdeaBuild polygenic scores that work in every ancestry before deploying any
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaStore adult-onset cancer gene results from newborn genomes and disclose at 18
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.