Automatic germline testing for every cancer type where it changes care
Anyone with ovarian, pancreatic, metastatic prostate or mismatch-repair-deficient cancer should be tested for inherited mutations, but many are not. Make it an automatic, opt-out lab step.
Guidelines recommend germline testing in these groups but rates are often under 50%. Propose reflex testing triggered by pathology (as reflex MMR/MSI testing already is), mainstreamed by oncologists with genetics support only for positives.
- Inherited risk is mostly unidentified · Most people who carry a high-risk cancer gene do not know it until they or a relative gets cancer.
Pages like this
not linked directly; found by shared links- IdeaLet clinics contact relatives directly when a cancer gene is found
Shares Germline vs somatic mutations, Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaOncology teams order germline tests; tele-genetic counsellors handle the results
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing, Ovarian cancer, Colorectal cancer.
- IdeaPopulation germline screening for hereditary cancer genes with cascade testing
Shares Germline vs somatic mutations, Inherited risk is mostly unidentified, Germline (hereditary) testing, Ovarian cancer.
- IdeaGo back to families of women who died of ovarian cancer and offer BRCA testing
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing, Ovarian cancer.
- IdeaUse a polygenic risk score to set when screening starts
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing, Prostate cancer, Colorectal cancer.
- Key paperCAPP2: two years of aspirin cuts bowel cancer in Lynch syndrome by more than a third over 10 years
Shares Germline vs somatic mutations, Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR), Inherited risk is mostly unidentified, Germline (hereditary) testing.
- CollectionClinVar
Shares Germline vs somatic mutations, Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaFamily history collected by app and matched to testing criteria automatically
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.