Build polygenic scores that work in every ancestry before deploying any
Genetic risk scores were built mostly on Europeans and work worse in others. Funding non-European cohorts and setting a portability standard would prevent screening that widens inequality.
Polygenic score accuracy drops substantially in African and South Asian ancestry. Propose a funding programme for diverse cohorts and a programme standard requiring PRS discrimination within 20% across ancestries before use in screening.
- Inherited risk is mostly unidentified · Most people who carry a high-risk cancer gene do not know it until they or a relative gets cancer.
- Trials do not represent the people who get cancer · Older, Black, Hispanic, Asian, rural, poor and multimorbid patients are under-represented, so results may not apply to them.
Pages like this
not linked directly; found by shared links- IdeaFamily history collected by app and matched to testing criteria automatically
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaBan life and disability insurers from using genetic results
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaStore adult-onset cancer gene results from newborn genomes and disclose at 18
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaA chatbot for pre-test genetic counselling so counsellors see only who needs them
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaGo back to families of women who died of ovarian cancer and offer BRCA testing
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaLet clinics contact relatives directly when a cancer gene is found
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.
- IdeaAncestry-aware pharmacology: drug-level sub-studies across populations before approval
Shares Germline (hereditary) testing, Trials do not represent the people who get cancer.
- IdeaOffer everyone at 30 a test for the cancer genes that matter
Shares Inherited risk is mostly unidentified, Germline (hereditary) testing.