Open Targets Platform
Open Targets scores how strongly each gene is linked to each disease, with the evidence behind it.
Includes ChEMBL drug data, safety liabilities, tractability, and Open Targets Genetics.
Pages like this
not linked directly; found by shared links- CollectionDrugBank & ChEMBL
Shares Pre-registered, publicly scored AI ranking of repurposing candidates for cancer, EMBL's European Bioinformatics Institute, No incentive to repurpose cheap drugs.
- IdeaAn open-science consortium on the undruggable drivers, open until a candidate
Shares A pre-competitive consortium to validate or kill academic targets before licensing, Secrecy and intellectual property block collaboration, AI-driven drug & target discovery, The undruggable drivers.
- CompanyIsomorphic Labs
Shares EMBL's European Bioinformatics Institute, AI-driven drug & target discovery, The valley of death between lab and product.
- CollectionDepMap (Cancer Dependency Map)
Shares A pre-competitive consortium to validate or kill academic targets before licensing, Wellcome Sanger Institute, The valley of death between lab and product, The undruggable drivers.
- IdeaA machine-readable taxonomy of why cancer drugs fail
Shares A target de-risking index that counts failures as well as successes, The valley of death between lab and product.
- IdeaAn open degrader consortium against every undruggable driver transcription factor
Shares Secrecy and intellectual property block collaboration, AI-driven drug & target discovery, The undruggable drivers.
- CollectionPubMed & Europe PMC
Shares An annual map of high-burden questions that nobody is funding, A registry for preclinical experiments that did not work, EMBL's European Bioinformatics Institute, Secrecy and intellectual property block collaboration.
- Key paperAlphaFold 2: predicting protein structures to near-experimental accuracy
Shares AI-driven drug & target discovery, The valley of death between lab and product, The undruggable drivers.