An open-science consortium on the undruggable drivers, open until a candidate
Companies and public funders would pool money and scientists to crack the hardest cancer proteins, such as MYC and mutant p53, sharing everything openly until there is a real drug candidate, then competing on the final product.
A consortium on the Structural Genomics Consortium and Open Targets model, but aimed at the highest-value undruggable oncology targets: MYC, mutant p53 reactivation, non-G12C RAS alleles beyond current inhibitors, fusion oncoproteins, transcription-factor and phosphatase targets. Members fund shared structural biology, chemical biology, degrader and molecular glue platforms and open probe generation, with an agreement that all results are published without patents up to the point of a validated chemical series, after which members may file and compete. The public benefit is a decade of duplicated, secret failure replaced by a shared map of what does and does not work.
- Secrecy and intellectual property block collaboration · Companies with complementary drugs rarely test them together, and data that could answer questions stays locked up.
- The undruggable drivers · The proteins that drive most cancers, such as MYC, mutant p53 and most RAS variants, still have no good drug.
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not linked directly; found by shared links- IdeaAn open degrader consortium against every undruggable driver transcription factor
Shares Secrecy and intellectual property block collaboration, AI-driven drug & target discovery, PROTACs & molecular glues (targeted protein degradation), TP53.
- IdeaExtend p53 reactivation beyond the Y220C mutation
Shares AI-driven drug & target discovery, p53 / RB / cell-cycle checkpoint, TP53, The undruggable drivers.
- IdeaDegrade the damaged p53 protein rather than trying to repair it
Shares p53 / RB / cell-cycle checkpoint, PROTACs & molecular glues (targeted protein degradation), TP53, The undruggable drivers.
- IdeaTurn a brake back on: drugs that reactivate the PP2A phosphatase
Shares RAS / RAF / MEK / ERK (MAPK), KRAS, The undruggable drivers.
- IdeaA precompetitive consortium for the twenty hardest cancer targets
Shares Broad Institute of MIT and Harvard, Secrecy and intellectual property block collaboration, The undruggable drivers.
- CollectionOpen Targets Platform
Shares A pre-competitive consortium to validate or kill academic targets before licensing, Secrecy and intellectual property block collaboration, AI-driven drug & target discovery, The undruggable drivers.
- ProductEprenetapopt
Shares p53 / RB / cell-cycle checkpoint, TP53, The undruggable drivers.
- IdeaAn open map of which cancer proteins any drug can stick to
Shares Broad Institute of MIT and Harvard, AI-driven drug & target discovery, The undruggable drivers.