An open map of which cancer proteins any drug can stick to
Most cancer proteins have never been tested to see whether a small molecule can attach to them at all. A public map of what is chemically reachable would tell the field where to aim.
Activity-based protein profiling with covalent fragment libraries can measure ligandable sites across thousands of proteins in cancer cell lysates and live cells. Existing datasets are partial and largely proprietary. A precompetitive atlas covering the cysteine, lysine and tyrosine proteomes across 50 cancer models, published openly with hit compounds deposited, would convert 'undruggable' from an assertion into a measurement.
- The undruggable drivers · The proteins that drive most cancers, such as MYC, mutant p53 and most RAS variants, still have no good drug.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
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not linked directly; found by shared links- IdeaA precompetitive consortium for the twenty hardest cancer targets
Shares The Institute of Cancer Research, Broad Institute of MIT and Harvard, The undruggable drivers.
- IdeaScore every model system on how well it predicted real trial results
Shares Broad Institute of MIT and Harvard, AI-driven drug & target discovery, Preclinical results do not reproduce.
- IdeaAttack the backup copy when a tumour has lost the original gene
Shares The Institute of Cancer Research, Broad Institute of MIT and Harvard, The undruggable drivers.
- IdeaA public biomarker validation utility with pre-diagnostic biobanks and blinded testing
Shares Proteomics & phosphoproteomics, Preclinical results do not reproduce.
- TechnologyBoltz-1 / Boltz-2 (MIT, open)
Shares Broad Institute of MIT and Harvard, AI-driven drug & target discovery.
- CollectionHuman Protein Atlas
Shares Proteomics & phosphoproteomics, Preclinical results do not reproduce.
- IdeaBreak up the liquid droplets where oncogenic transcription happens
Shares Broad Institute of MIT and Harvard, The undruggable drivers.
- InstitutionFrederick National Laboratory for Cancer Research
Shares Proteomics & phosphoproteomics, AI-driven drug & target discovery, The undruggable drivers.